Document Type : Article
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Department of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Alzheimer's disease (AD) is characterized by amyloid plaques and neuronal death ultimately leading to dementia. Using natural therapies has always been a great concern for AD. Herein, Geraniol, as a natural monoterpene, was applied to examine its protective and therapeutic effects on a rat model of AD. In order to create Alzheimer’s rat model, bilateral injection of Amyloid β1–42 (Aβ1–42) was performed into rats’ hippocampus. Both therapeutic (post-AD induction) and protective effects of Geraniol consumption (100 mg/kg) were investigated on the antioxidant and brain histological parameters. In addition, Aβ1–42 peptide was driven toward fibril formation in vitro and effect of Geraniol (100 µM) was observed on Aβ1–42 fibrils. Alzheimer’s-induced group showed impairment in the antioxidant parameters along with loss of neuronal cells and amyloid plaque formation. Administration of Geraniol, in both treatment and protective modes, increased neurogenesis, reduced amyloid plaques, and improved antioxidant parameters. Therefore, Geraniol showed capability of improving AD signs as well as direct anti-fibril effect and it could be considered as neuroprotective.