Synthesis and Characterization of Dendrimer-Modified Graphene Oxide Nanocarrier for Loading and Releasing Carboplatin

Document Type : Article

Authors

1 Department of Chemistry, Gorgan Branch, Islamic Azad University, Gorgan, Iran

2 Department of Chemistry, Varamin (Pishva) Branch, Islamic Azad University, Varamin, Iran

3 Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran

Abstract

Carboplatin is a well-known anticancer drug. It, as a targeted medicine, is loaded onto branched graphene oxide nanoparticles (GONPs). In the present study, polymeric coatings with chitosan (CS) bonded of the fifth dendrimer’s generation containing the groups of ethylenediamine (EDA) and methyl methacrylate (MMA) function as a responsive polymer. In order to formulate the dendrimer coating, the graphene oxide surface’s last carrier, the precursors are polymerized. Chitosan (polymer sensitive to pH) coating is then applied to the branched graphene oxide surface. Further, the drug release is raised. The final product’s average size is 42 nm. The FTIR, TGA, XRD, and SEM-EDX are applied to characterize its various adsorption properties. Physical factors of several adsorption processes, including time, pH, and temperature, are examined applying the final adsorbent. The drug release using the adsorbent coated with a polymer sensitive to pH is more than that without. Drug release tests show pH sensitivity behavior in graphene oxide/dendrimer/chitosan (GO/dendrimer/CS) with %98.8 drug release at acidic (pH = 5.6) and %90 at neutral (pH = 7.4) settings, i.e., in the tumorous cell and the blood pH levels, respectively.

Keywords

Biomacromolecular Journal
Volume 6, Issue 2
December 2020
Pages 173-181

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