Document Type : Review
Bio-Analysis Lab, Institute of Biochemistry and Biophysics (IBB), University of Tehran
University of Tehran
The Bio-Analysis Lab (with former name of Microanalysis Lab) was established in 1975 at the Institute of Biochemistry and Biophysics, University of Tehran. Many research works and studies have been carrying out in this lab such as electrochemistry of proteins, design and development of nanoparticles for development of novel biosensors, structural analysis of proteins by electrochemistry development of enzyme/microbial biofuel cells. For these purposes, different electrochemical and spectroscopic techniques and various imaging methods were used. In the present report, at first the direct electrochemistry of enzymes such as glucose oxidase, horseradish peroxidase, catalase, euphorbia latex amine oxidase, superoxide dismutase and horse heart cytochrome c were considered. Then, the methods for applying different types of macromolecules such as enzymes, antibodies, nucleic acids and aptamers for developing different types of optical and electrochemical biosensors were illustrated. At the end, some biocompatible nanoparticles for biomedical applications including cancer therapy and also application of some nanomaterials for improving the efficiency of biofuel cells were reviewed.