TY - JOUR ID - 243948 TI - The Effect of Nerol on Biochemical and Histological Parameters in Nonalcoholic Fatty Liver Disease in NMRI Mice JO - Biomacromolecular Journal JA - BMMJ LA - en SN - 7280-2423 AU - Givian, Mandana AU - Ghobeh, Maryam AU - Yaghmaei, Parichehreh AD - Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran Y1 - 2020 PY - 2020 VL - 6 IS - 1 SP - 33 EP - 45 KW - Nerol KW - Nonalcoholic fatty liver KW - Lipid profiles KW - Antioxidant and liver enzymes KW - Glucose DO - N2 - Fatty liver contains a range of clinical symptoms, including the accumulation of fat in the liver cells and it varies from a simple steatosis to nonalcoholic steatohepatitis and cirrhosis. Using natural therapies has always been a great concern for such health-related diseases. Herein, nerol, as a natural monoterpene, was applied to treat nonalcoholic fatty liver-induced NMRI (Naval Medical Research Institute) mice. The assessment included histological studies of the liver along with measurement of biochemical parameters, including insulin, glucose, HDL-C (high-density lipoprotein cholesterol), LDL-C (low-density lipoprotein cholesterol), Aspartate transaminase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), SOD (superoxide dismutase), and catalase. The results demonstrated that treatment with nerol (90 mg/kg) modified the fatty liver indices by significantly reducing the levels of triglyceride, cholesterol, LDL-C, glucose, and insulin (p <0.001) whereas this treatment notably increased the levels of liver antioxidant enzymes, and HDL-C (p <0.001). Nerol administration also improved the status of the liver tissue of the fatty liver condition. Therefore, nerol, in a dose-dependent mode, showed capability of improving nonalcoholic fatty liver and could offer a reliable remedy. UR - https://www.bmmj.org/article_243948.html L1 - https://www.bmmj.org/article_243948_5ef093141fa9036aed5d9529ea42c1ee.pdf ER -