Gas Plasma for Medical Applications: Wound Healing and Oncotherapy

Document Type : Review


1 Plasma Medicine Group, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Institute for Plasma Research and Department of Physics, Kharazmi University, Tehran, Iran

2 Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran


Cancer and wound healing lead to high mortality and healthcare problems. To provide therapeutic insights into oncotherapy and wound healing challenges, there is an urgent need for novel technologies. The use of physical plasma for medical purposes is known as medical plasma and this field consists of plasma physics, biochemistry, biology, and medicine. Plasma medicine is one of the most innovative and emerging areas and provides a promising strategy for a variety of diseases including wound healing, cancer therapy, biofilm removal, virus inactivation, dentistry, and ophthalmology. The discovery of the multimodal nature of gas plasma (GP) for widespread medical applications revealed that its efficacy is related to the reactive oxygen and nitrogen species, electric field, and UV radiation. The combination of these agents brings about a unique platform for medicine. Here, along with summarizing the nature of GP, wound healing, and cancer, we review some of the latest work regarding the application of GP for oncotherapy and wound healing.

Graphical Abstract

Gas Plasma for Medical Applications: Wound Healing and Oncotherapy