Factors Affecting the Inhibition of Survivin Degradation

Document Type : Article


Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran


One family of anti-apoptotic proteins named the inhibitor of apoptosis proteins (IAPs) prevents cell death by blocking the downstream region of the caspase activation pathways. Survivin is a small member of the family of proteins that suppress apoptosis. Survivin performs various tasks that help cancer cells survival, including cytoprotection, preventing cell death, and controlling the cell cycle, particularly during the mitotic process. Cancer cells may survive with the help of survivin, as it is consistently up-regulated in human tumors, connected to poor prognosis, resistance to chemotherapy or radiation therapy, and associated with these treatments. Survivin is often regulated at two levels: the transcriptional level and the post-translational levels. In this review, the different proteins influence the progression of survivin degradation in post-translation adjustment were discussed such as FAT10, Usp22, Csn5; and LNC473. Finding and developing a therapy strategy that can adequately address the range of the aforementioned issues might be aided by understanding regulators and their mechanisms of action.


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