Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Abstract
Fatty liver contains a range of clinical symptoms, including the accumulation of fat in the liver cells and it varies from a simple steatosis to nonalcoholic steatohepatitis and cirrhosis. Using natural therapies has always been a great concern for such health-related diseases. Herein, nerol, as a natural monoterpene, was applied to treat nonalcoholic fatty liver-induced NMRI (Naval Medical Research Institute) mice. The assessment included histological studies of the liver along with measurement of biochemical parameters, including insulin, glucose, HDL-C (high-density lipoprotein cholesterol), LDL-C (low-density lipoprotein cholesterol), Aspartate transaminase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), SOD (superoxide dismutase), and catalase. The results demonstrated that treatment with nerol (90 mg/kg) modified the fatty liver indices by significantly reducing the levels of triglyceride, cholesterol, LDL-C, glucose, and insulin (p <0.001) whereas this treatment notably increased the levels of liver antioxidant enzymes, and HDL-C (p <0.001). Nerol administration also improved the status of the liver tissue of the fatty liver condition. Therefore, nerol, in a dose-dependent mode, showed capability of improving nonalcoholic fatty liver and could offer a reliable remedy.
Givian, M., Ghobeh, M., & Yaghmaei, P. (2020). The Effect of Nerol on Biochemical and Histological Parameters in Nonalcoholic Fatty Liver Disease in NMRI Mice. Biomacromolecular Journal, 6(1), 33-45.
MLA
Mandana Givian; Maryam Ghobeh; Parichehreh Yaghmaei. "The Effect of Nerol on Biochemical and Histological Parameters in Nonalcoholic Fatty Liver Disease in NMRI Mice". Biomacromolecular Journal, 6, 1, 2020, 33-45.
HARVARD
Givian, M., Ghobeh, M., Yaghmaei, P. (2020). 'The Effect of Nerol on Biochemical and Histological Parameters in Nonalcoholic Fatty Liver Disease in NMRI Mice', Biomacromolecular Journal, 6(1), pp. 33-45.
VANCOUVER
Givian, M., Ghobeh, M., Yaghmaei, P. The Effect of Nerol on Biochemical and Histological Parameters in Nonalcoholic Fatty Liver Disease in NMRI Mice. Biomacromolecular Journal, 2020; 6(1): 33-45.
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